by Antithrombin Interfere with the Inactivation of Thrombin the Antiphospholipid Syndrome That Identification of Anti-Thrombin Antibodies in
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منابع مشابه
Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin.
We previously reported that some human antiphospholipid Abs (aPL) in patients with the antiphospholipid syndrome (APS) bind to the homologous enzymatic domains of thrombin and the activated coagulation factor X (FXa). Moreover, some of the reactive Abs are prothrombotic and interfere with inactivation of thrombin and FXa by antithrombin (AT). Considering the enzymatic domain of activated coagul...
متن کاملInteractions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis
OBJECTIVE To characterize the interaction between procoagulant and/or anticoagulant serine proteases and human monoclonal IgG antiphospholipid antibodies (aPL) and polyclonal IgG derived from patients with the antiphospholipid syndrome (APS). METHODS Five human monoclonal IgG with small differences in their sequences were tested for binding to protein C, activated protein C, plasmin, factor V...
متن کاملIdentification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin.
The combined presence of anti-phospholipid Ab (aPL) and thrombosis is recognized as the antiphospholipid syndrome (APS). The aPL represent a heterogeneous group of Ab that recognize various phospholipids (PL), PL-binding plasma proteins, and/or PL-protein complexes. Recently, we found the presence of antithrombin Ab in some APS patients and that some of these anti-thrombin Ab could inhibit thro...
متن کاملAnti-tissue factor pathway inhibitor activity in subjects with antiphospholipid syndrome is associated with increased thrombin generation.
BACKGROUND AND OBJECTIVES Immunoglobulin G (IgG) fractions from subjects with antiphospholipid syndrome (aPS) have previously been demonstrated to have inhibitory activity against tissue factor pathway inhibitor (TFPI). This may contribute to the development of a prothrombotic state by impaired regulation of the tissue factor (TF) pathway. This study investigated the effect that IgG fractions f...
متن کاملDetermination of Diagnostic Value of Albumin, Anti Thrombin Ш, and Fibrinogen Factors in the Diagnosis of Pulmonary Embolism Compared to Lung Perfusion Scan in Patients with Nephrotic Syndrome
Bachground: The aim of this study was to determine of diagnostic value of albumin, anti-thrombin Ш, and fibrinogen factors in the diagnosis of pulmonary embolism compared to lung perfusion scan in patients with nephrotic syndrome referred to Hazrat Ali Asghar hospital of Tehran city (Iran) in 2018-2019. Methods: This study was cross sectional study that was carried out on 30 patients with nep...
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